Patient Name: Owner Name: Species: Canine Feline. Dosage Dilute dexdomitor (0.5 mg/mL) using 0.1 mL dexdomitor with 0.9 mL saline or sterile water to make 0.05 mg/mL dexdomitor solution. 1 Study flow chart. 1Pinkel D . A large proportion of patients in both groups received opioid analgesics; however, more patients in the HD-DEX group required both sedatives and antipsychotics ( Table 2 ). PDF the same safe, reliable sedation and analgesia as ... PDF Sedation - Canine - Zoetis | zoetisUS.com An eye lubricant should be applied to cats to prevent corneal desiccation that may result from a reduction in the blink reflex. 4.4-7 2-3 28.1 0.12 40 0.15 weight in cats. The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. greater DEXDOMITOR requirement per unit body weight than larger dogs (eg, dogs weighing more than 16 kg) The above chart is a representation of BSA dosing with DEXDOMITOR being used as a sole agent. PDF What dose of methadone should I use? - Dechra Pharmaceuticals The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the . PDF 0.010 mg/kg Weight (Kgs) mL Weight (Lbs) - ASPCApro Methods: Outpatient children aged three months to three years with diverse diagnoses of congenital heart disease, including cyanotic . -Initial Dose: Loading dose of 1 mcg/kg IV infusion over 10 minutes. The concentration -Initial Dose (including Awake Fiberoptic Intubation): 1 mcg/kg IV infusion over 10 minutes. h) of dexmedetomidine can be safely administered in critically ill (ASA III) patients with severe scoliosis undergoing intraoperative wake-up test during SOSCS. DEXDOMITOR® (dexmedetomidine hydrochloride) • Administer 0.1 mL /10 lbs IV of this diluted mixture. References: Nagelhout. Table 2: CANINE PREANESTHESIA DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight. Calculators for Emergency and Anesthetic drugs, Constant Rate Infusions (CRI), IV Fluid Rates, Chocolate Toxicity, Calorie requirements for dogs and cats and Unit conversion (including Weight, Temperature, Body Surface Area, mg to ug, cc's to ounces's, cm's to inches). in cats Pack size: 1 x 10 ml PDF Telazol-Torbugesic-Dexdomitor (TTDex) Sedation/anesthesia ... • DEXDOMITOR 0.1 allows a larger dose volume for small dogs, increasing accuracy, consistency and predictability. Atipamezole should be used as needed at the end of the surgical procedure to facilitate recovery; partial dosing is suggested (1/5 to 1/2 dexmedetomidine volume). It is recommended that dogs and cats be fasted for 12 hours before treatment with DEXDOMITOR. Dose chart for kitty magic combination Dexdomitor-Opioid-Ketamine Sedation/analgesia In Cats Cat Weight Volume Dexdomitor Butorphanol- Ketamine IM route Lbs Kg Light Mild Moderate Profound /Surgery 4 -7 2-3 0.012 mL 0.025 mL 0.05 mL 0.1-0.15 mL 7-9 3-4 0.025 mL 0.05 mL 0.1 mL 0.2-0.25 mL Sileo (dexmedetomidine oromucosal gel) is the first and only FDA-approved treatment for dogs that suffer from noise aversion. Dexmedetomidine in the Treatment of Agitation Associated ... Evaluate the health status of your canine or feline patient. Dexdomitor 0.1 for Animal Use - Drugs.com If a patient was not adequately sedated XLS VASG Dog & Cat Anesthesia & Pain Management Support The median total dexmedetomidine infusion dose over the first 24 hours was 13.6 mcg/kg (range, 11.8—15.3) in the patients who required dialysis. Referenced from Jeff C.H. in dogs 0.05-1.30 ml i.m. Draw 1 ml of Dexmedetomidine (0.5 mg/ml) into a sterile syringe and dispense into a sterile multi‐dose vial. Feline dosing chart DEXDOMITOR® 0.1 mg/mL (dexmedetomidine) Sedation/analgesia in cats 40 mcg/kg IM mL 1.0 Feline Weight lb 4.1-7 kg 2.1-3 2-4 1-2 0.5 specifically made for cats that weigh 7 lb or less; The same safe, reliable sedation and analgesia as DEXDOMITOR; For higher weight ranges, use DEXDOMITOR® (dexmedetomidine), the 0.5 mg/mL Pediatric Spinal Fusion for Scoliosis . 2. 4th edition. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride. c) Dosage. Dexmedesed ® is also indicated for use as a preanesthetic to general anesthesia in dogs and cats. For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart. DEXDOMITOR and ANTISEDAN are trademarks owned by Orion Corporation and Orion Pharma. Idiopathic scoliosis (no definite cause) is the most common form of the condition (>70%), and it mainly affects adolescent girls. Prolonged exposure to dexmedetomidine beyond 24 hours may be associated with tolerance and tachyphylaxis and a dose-related increase in adverse events ADVERSE REACTIONS The most common adverse reactions (incidence greater than 2%) are hypotension, bradycardia, and dry mouth. Dose based on codeine (1-2 mg/kg q8-12 hrs) but limited by acetaminophen (not to exceed 10-15 mg/kg q8-12hrs) Example: 1-2 tablets listed at left per 30 kg dog q8-12hrs Canine Quick Dosage Sheet The International Veterinary Academy of Pain Management (IVAPM) is the leading forum and educational source for veterinary professionals interested Dexdomitor ® (dexmedetomidine hydrochloride) is a synthetic alpha 2 -adrenoreceptor agonist with sedative and analgesic properties. The duration of sedation increased with the dosage level. Canine Dosing Chart. Feline Dosing Chart DEXDOMITOR® (dexmedetomidine) - 0.5 mg/mL Body Surface Area dosing may be a consideration for cats of smaller body weight. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine . Usual Adult Dose for Sedation. Dexmedesed ® provides 0.5 mg/mL of dexmedetomidine hydrochloride and is available in 10 mL vials. ENTER BODY WEIGHT: KGS. A collection of drug calculators for Veterinarians and support staff. Emergence delirium was most commonly assessed 0.7 microgram/kg/hour, adjusted according to response; usual dose 0.2-1.4 micrograms/kg/hour. • If no IV access, give 0.3 mL/10 lbs IM. Feline DEXDOMITOR Dosing Dose (mcg/kg) Body Weight (kg and lb) 20 40 60 80 4 8 12 16 20 24 28 32 36 40 . Use of a loading dose of Dexdorin ICU sedationis notrecommended andis associated with increased adverse reactions. Common noise aversion triggers include fireworks, thunder, construction work, traffic or street noise . Precedex (dexmedetomidine hydrochloride) in 0.9% Sodium Chloride Injection is a sterile, nonpyrogenic ready to use solution suitable for intravenous infusion. For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart. In a clinical study, prolonged infusions of dexmedetomidine at doses up to 1.4 microgram/kg/hr were not Important safety information Dexmedetomidine should only be administered by, or under the direct supervision of, personnel experienced in its use, with adequate training in anaesthesia and airway management. Start at 0.7 microgram/kg/hour for 1 hour then titrate by increments of 0.1 to 0.2 microgram/kg/hour every hour to achieve light sedation. Contraindicated. Select desired level of sedation. The chemical name is (+)-4- [ (S)-α, 2,3-trimethylbenzyl]imidazole hydrochloride. These products are developed and manufactured by Orion As with all drugs, side effects may occur. Label the vial with Dexmedetomidine 0.25 mg/kg, the date prepared and the expiry date. For use in dogs, the dexmedetomidine dose is sometimes decreased slightly and the opioid volume may increase, depending on drug selection Induction for a 4.5 kg (10lb) cat would be: 0.2 mL of 0.5 mg/ml dexmedetomidine + To prepare the infusion, withdraw 2 mL of Precedex Injection, and add to 48 . Dexmedetomidine administered at CRIs > 0.5 mcg/kg/min have the potential for use during anesthesia in dogs because it reduces the MAC of isoflurane. greater DEXDOMITOR requirement per unit body weight than larger dogs (eg, dogs weighing more than 16 kg) The above chart is a representation of BSA dosing with DEXDOMITOR being used as a sole agent. Table 3: FELINE DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight in cats. Do not use Dexmedesed in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney . Effects of Dexmedetomidine on motor- and somatosensory-evoked potentials in patients with thoracic spinal cord tumor: a randomized controlled trial. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic . 527 Like propofol, it has a rapid onset and a relatively rapid elimination half-life and is administered as a loading dose followed . Veterinary Drug Calculator website and App for Veterinarians and support staff. To this, add 1 ml of sterile, pyrogen‐ free water or sterile 0.9% NaCl. Calculators for Emergency and Anesthetic drugs, Constant Rate Infusions (CRI), IV Fluid Rates, Chocolate Toxicity, Calorie requirements for dogs and cats and Unit conversion (including Weight, Temperature, Body Surface Area, mg to ug, cc's to ounces's, cm's to inches). SPC dose rates for Comfortan® •dogs: 0.5-1.0 mg/kg SC, IM or IV •cats: 0.3-0.6 mg/kg IM only the upper end of these dose ranges should not be the primary starting point i.e. An IV anesthetic agent or inhalant anesthetic should be available for patients that become light during the procedure. The pharmacokinetics of dexmedetomidine is linear in the dosing range from 0.2 to 1.4 µg/kg/h and it does not accumulate in treatments lasting up to 14 days. the higher doses should only be reached following upwards titration from a lower dose Preparation of solutions is the same, whether for the loading dose or maintenance infusion. Dogs: DEXDOMITOR produces sedation and analgesia when administered intramuscularly (IM) at a dose of 500 mcg/m 2, or intravenously (IV) at a dose of 375 mcg/m 2. Yan. Loading dose of 0.5 μg/kg of dexmedetomidine was given to all the children after intubation for 10 minutes using an infusion pump. Do NOT bolus 2016. An eye lubricant should be applied to cats to prevent corneal desiccation that may result from a reduction in the blink reflex. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. Dexmedetomidine binds to both human serum albumin and . Dexmedetomidine 7-15 μg/kg IM (dog) or 10-20 μg/kg IM (cat) Neurosteroid Alfaxalone 1-2 mg IM§ Dissociative Ketamine 1-2 mg/kg IM How to use this chart: 1. For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart. Each ml of SILEO contains 0.09 mg dexmedetomidine (equivalent to 0.1 mg dexmedetomidine hydrochloride). It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236.7. It is prescribed by your veterinarian to help keep your dog calm when he or she hears scary noises. To make up a micro-dose of Dexdomitor - Take 0.1 ml of Dexdomitor (500 mcg/mL) and dilute with 0.9 ml of saline (or sterile water) to form 50 mcg/mL concentration of Dexdomitor solution. In addition, bubble charts were drawn based on the dose of dexmedetomidine and pain score of POD1, and the results showed no significant trend in pain scores as dexmedetomidine dose increased, although it was not statistically significant (Figure 3B). The #1 Veterinary Drug Calculator website and the #1 Veterinary Apps Drug Calculator! Dexmedetomidine is an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative properties. Patients failing to achieve an adequate level of sedation with the maximum dose of dexmedetomidine should be switched to an alternative sedative agent. Canine DEXDOMITOR Dosing 1.13 Dose (mcg/kg) Body Weight (kg and lb) 0 5 10 15 20 25 30 35 40 45 4 8 12 16 20 24 28 32 36 40 44 48 52 56 60 64 68 8.8 kg It is a white, or almost white, crystalline, water soluble . DOSAGE CALCULATOR. Injectable Perianesthetic Medications for Canine/Feline. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. SILEO (dexmedetomidine oromucosal gel) is a synthetic alpha-2 adrenoceptor agonist. This medication is prescribed by your veterinarian to help calm your dog when your pet is frightened by loud noises. field for calculation. The above chart is a representation of BSA dosing with DEXDOMITOR 0.1 being used as a sole agent. DEXDOMITOR® (dexmedetomidine) - 0.5 mg/mL Interactive dosing Calculator at dexdomitorUsA.com Sedation & Preanesthetic - Feline Feline DEXDOMITOR Dosing This chart is a representation of BSA dosing as compared to the FDA-approved feline dose. Drug name Administration Dosing instruction How to titrate Monitoring/Other information Nicardipine (2mg/2ml) Max conc: 10 mg/100 mL .2mg/mL Solution: NSS, D5W, D5NS Infusion: 5 - 15 mg/h (see drip chart) Titrate dose by 2.5 mg/h q 15 mins to achieve BP. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose. Precedex (dexmedetomidine hydrochloride) Injection Precedex (dexmedetomidine hydrochloride) Injection, Concentrate For intravenous infusion of injection following dilution of concentrate Initial U.S. Approval: 1999 -----INDICATIONS AND USAGE----- Precedex is a relatively selective alpha in dogs 0.2-1.9 ml i.m. • Duration of micro-dose is approximately 5-8 . the use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. Administer 0.1 mL per 10 lbs, IV of this diluted Dexdomitor-saline mixture to treat rough recovery. Dexmedetomidine is 94% bound to plasma proteins. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given . Dexmedetomidine dosing ranged from 0.15 to 2 μg/kg.10-16 The timing of administration occurred shortly after induction11-13,15 or before emergence.14 Additionally, the included sources investigated ED as either a primary 10-14,16 or secondary15 outcome. Dexdor (dexmedetomidine) is contraindicated in hypersensitivity to the active substance or to any of the excipients, in advanced heart block (grade 2 or 3) unless paced, in uncontrolled hypotension, in acute cerebrovascular conditions. Dexmedetomidine had no effect on ACTH-stimulated cortisol release in dogs after a single dose; however, after the subcutaneous (SC) infusion of dexmedetomidine for one week, the cortisol response to ACTH was diminished by approximately 40%. Use of dexmedetomidine HCl beyond 24 hours has been associated with tolerance (reduction in response after longer duration; a higher dosage of dexmedetomidine HCl is required to produce the same effect that was obtained at a lower dosage); tachyphylaxis (a sudden decrease in response); and a dosage-related increase in adverse reactions. i) Diluting 10 mg/ml acepromazine to 1 or 2 mg/ml helps facilitate more accurate dosing, especially when managing smaller patients. Dose based on codeine (1-2 mg/kg q8-12 hrs) but limited by acetaminophen (not to exceed 10-15 mg/kg q8-12hrs) Example: 1-2 tablets listed at left per 30 kg dog q8-12hrs . The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. • For small dogs, dose volume with DEXDOMITOR (0.5mg/mL) is low; there is a potential for underdosing or overdosing. For higher weight ranges, use DEXDOMITOR® (dexmedetomidine), the 0.5 mg/mL . Also includes normal laboratory reference ranges for . This amounts to approximately one mcg/kg of Dexdomitor. Ethnic and Use of low dose dexmedetomidine in combination with genetic determinants of cardiovascular response to the opioids and midazolam in paediatric cardiac surgical selective 2-adrenoceptor agonist dexmedetomidine. Calculators for Emergency and Anesthetic drugs, Constant Rate Infusions (CRI), IV Fluid Rates, Chocolate Toxicity, Calorie requirements for dogs and cats and Unit conversion (including Weight, Temperature, Body Surface Area, mg to ug, cc's to ounces's, cm's to inches). Consider the combinations available. end of the dose is used for moderate sedation, the high end of the dose for deep sedation/ induction/light anesthesia. A decreased respiratory rate was observed in all groups on each day, but returned to normal within 4 hours in the low IV and IM groups and within 8 hours in the mid and high IV . 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